Monday, September 18, 2017


by: Dr. Jesse A. Stoff

Chronic Fatigue Syndrome (CFS) occurs in people who are suffering from overwhelming levels of stress for a prolonged period of time. As a result of that stress, there's a progressive weakening of certain endocrine pathways in our system, a weakening of our adrenals, stress in our thyroid gland, so on, and so forth. So ultimately, these organs go out of balance, and out of condition, and out of their normal response range. As soon as there's a shift in the endocrine response, there's a secondary effect on the functioning of our immune system pre-disposing us to infections from various sorts of viruses. There are a number of different viruses that are associated with chronic fatigue syndrome. Research is continuing, but some of them include things like Epstein-Barr virus, Cytomegalovirus, HHV6, Coxsackie B, and others. As I said, the research is continuing.

The common denominator is that the person who is suffering from a situation where their immune system has become confused and damaged, and doesn't protect them the way that it should. Also, their endocrine system, the balance of hormones, is somewhat out of whack in terms of their function of their adrenals and their thyroid. This sort of fatigue that results can be a bone-tired sort of fatigue where the person may get eight, 10, 12 hours of rock solid sleep, wake up in the morning, and feel like they haven't slept for two minutes. This is a sort of fatigue that when they try to go out and do the simplest tasks in their life, to go shopping, to go to work, to take a walk, simple exercise, halfway through, they find they have to sit down, rest or even take a nap. It can be a very, very debilitating disease.

And yet, when you look at the person they may look well, their skin color may be good, the skin tone may be good, lots of nice bushy hair. They may not look sick, but the way that they feel can be completely debilitating. Unfortunately, there's no one blood test for chronic fatigue syndrome, which adds to the problems and the confusion about this disorder. Chronic fatigue syndrome is a syndrome. It's a collection of symptoms. It's not a specific disease, per se. When somebody has chronic fatigue syndrome, the first thing that we do is a differential diagnosis. We'll do a number of different blood tests to see if somebody's suffering from something else that has to be treated very specifically, such as Lyme disease, or some babesia, or from mononucleosis, or from diabetes, or from thyroiditis, and on and on. If we can identify some other distant disease that can account for the symptoms, that then becomes the target, that then becomes their diagnosis until it is resolved and put back into a state of cure or remission, and then, we see what symptoms are left, if any.

If the person doesn't have any known identifiable disease or disorder, then we're left with chronic fatigue syndrome. The way that we address chronic fatigue syndrome is by looking at the balance of the immune system, looking at the inflammatory markers that it is making, looking at the balance of the major pathways of the immune system, looking at the various hormones that the adrenals and thyroid are making, which are responsible for our energy production and stamina, looking at the relationship, looking at the ratios, correcting things as necessary; and then, doing some very specialized blood tests to try to get a better idea of how the mitochondria are working. Mitochondria are like little power houses that are located in each and every one of our cells throughout our entire body.

One of the characteristics of chronic fatigue syndrome when people are doing research on this disorder, is that they find that there is a dysfunction of the mitochondria: A decrease in the number of the mitochondria, and a decrease in their ability to produce the energy molecule called ATP. However, the good news is that research has also been going on on ways to support the mitochondria, to stimulate the production of ATP, and to actually stimulate the production of their number and how to stimulate the production of new mitochondria. So the bottom line is that through a comprehensive evaluation of the person who's suffering from chronic fatigue syndrome, we can put together an individualized treatment protocol that can help to stabilize the symptoms that they're having, and over a period of time, to reverse the syndrome that they're suffering from, so they could have a long, healthy, and happy life. 

DR. JESSE A. STOFF is an internationally renowned physician with extensive credentials in clinical immunology and holistic medicine. A graduate of New York Medical College, he pursued extensive post-doctoral training including a fellow- ship at the Royal London Homeopathic Hospital in LondonEngland. He has authored/co-authored countless articles and 8 books including co-authoring the bestseller "Chronic Fatigue Syndrome: The Hidden Epidemic" and The Prostate Miracle.

This article is produced and written by the writing team at IMMUNOLOGY TODAY- The Official Newsletter of Integrative Medicine of N.Y. of Westbury NY-- Edited and co-published by Dr. Jesse A. Stoff exclusively for the purposes of this blogpost (Immunology Today) and The publisher(s) hold all rights (c) to all elements, images and content herein.  All distribution, sharing or re-posting of this article is only with the express permission from Dr. Stoff and Integrative Medicine of NY (formerly Linchitz Medical Wellness). 265 Post Ave. Suite 380 Westbury, NY 11590  |  516.759.4200  |   Rejuvenate! is a registered trademark of Intermedia Communications Ltd. All written content in this newsletter is produced by the Stoff Institute for Medical Research (SIMR) exclusively for private distribution at the Integrative Medicine of NY ©2016- All Rights Reserved.

DISCLAIMER: Integrative Medicine of NY (formerly Linchitz Medical Wellness) and Dr. Jesse A. Stoff make no claims pertaining to any of the institutions or funding information listed, make no warranty or guarantee of funding, and bear no responsibility and disclaim any liability for the privacy of communications or the outcome of any applications for the listed resources. No further information about any of the institutions nor funding programs (other than the links and contact information listed here) is available.  Written content provided in this article/blog is for informational purposes only; consult your physician before making any changes to your treatment plan.

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